MEG evaluation of Parkinson's diseased patients after external magnetic stimulation

Magnetoencephalographic (MEG) recordings of Parkinson's diseased (PD) patients were obtained using a whole-head 122-channel magnetometer and analyzed with Fourier statistical analysis. External transcranial magnetic stimulation (TMS) in the order of pico Tesla was applied on the above patients...

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Bibliographic Details
Published inActa neurologica Belgica Vol. 107; no. 1; p. 5
Main Authors Anninos, P, Adamopoulos, A, Kotini, A, Tsagas, N, Tamiolakis, D, Prassopoulos, P
Format Journal Article
LanguageEnglish
Published Italy 01.03.2007
Subjects
Aged
Aged, 80 and over
Dyskinesia, Drug-Induced - physiopathology
Dyskinesia, Drug-Induced - therapy
Evoked Potentials - physiology
Female
Humans
Magnetoencephalography - methods
Male
Middle Aged
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Perceptual Disorders - etiology
Perceptual Disorders - physiopathology
Recovery of Function - physiology
Transcranial Magnetic Stimulation - adverse effects
Transcranial Magnetic Stimulation - methods
Treatment Outcome
Tremor - etiology
Tremor - physiopathology
Tremor - therapy
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Summary:Magnetoencephalographic (MEG) recordings of Parkinson's diseased (PD) patients were obtained using a whole-head 122-channel magnetometer and analyzed with Fourier statistical analysis. External transcranial magnetic stimulation (TMS) in the order of pico Tesla was applied on the above patients with proper field characteristics (magnetic amplitude : 1-7.5 pT, frequency : the alpha-rhythm of the patient: 8-13 Hz) which were obtained prior to TMS. The MEG recordings after the application of TMS showed a rapid attenuation of the high abnormal activity followed by an increase of the low frequency components toward the patients' alpha-rhythm. The patients responded to the TMS with a feeling of relaxation and partial or complete disappearance of tremor, muscular ache and levodopa induced dyskinesias as well as rapid reversed visuospatial impairment, which were followed by a corresponding improvement and normalization of the MEG.
ISSN:0300-9009