Does histologic chorioamnionitis correspond to clinical chorioamnionitis?

To evaluate the degree to which histologic chorioamnionitis, a frequent finding in placentas submitted for histopathologic evaluation, correlates with clinical indicators of infection in the mother. A retrospective review was performed on 52 cases with a histologic diagnosis of acute chorioamnioniti...

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Bibliographic Details
Published inJournal of reproductive medicine Vol. 53; no. 1; p. 25
Main Authors Heller, Debra S, Rimpel, Lisa Howard, Skurnick, Joan H
Format Journal Article
LanguageEnglish
Published United States 01.01.2008
Subjects
Adult
Anti-Bacterial Agents - therapeutic use
Case-Control Studies
Chorioamnionitis - diagnosis
Chorioamnionitis - pathology
Diagnosis, Differential
Female
Gestational Age
Humans
Infant, Newborn
Lymphocyte Count
Placenta - pathology
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - pathology
Pregnancy Trimester, Third
Puerperal Infection - diagnosis
Puerperal Infection - pathology
Retrospective Studies
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Summary:To evaluate the degree to which histologic chorioamnionitis, a frequent finding in placentas submitted for histopathologic evaluation, correlates with clinical indicators of infection in the mother. A retrospective review was performed on 52 cases with a histologic diagnosis of acute chorioamnionitis from 2,051 deliveries at University Hospital, Newark, from January 2003 to July 2003. Third-trimester placentas without histologic chorioamnionitis (n = 52) served as controls. Cases and controls were selected sequentially. Maternal medical records were reviewed for indicators of maternal infection. Histologic chorioamnionitis was significantly associated with the usage of antibiotics (p = 0.0095) and a higher mean white blood cell count (p = 0.018). The presence of 1 or more clinical indicators was significantly associated with the presence of histologic chorioamnionitis (p = 0.019). Histologic chorioamnionitis is a reliable indicator of infection whether or not it is clinically apparent.
ISSN:0024-7758