Tubulointerstitial macrophage infiltration in a patient with hypokalemic nephropathy and primary Sjögren's syndrome

We report a case of hypokalemic nephropathy associated with primary Sjögren's syndrome (SS). The patient presented with profound and persistent hypokalemia secondary to distal renal tubular acidosis (RTA). A renal biopsy exhibited tubular degeneration, marked interstitial fibrosis and intense m...

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Published inClinical nephrology Vol. 64; no. 5; p. 387
Main Authors Harada, K, Akai, Y, Iwano, M, Nakatani, K, Nishino, T, Fujimoto, T, Shiiki, H, Saito, Y
Format Journal Article
LanguageEnglish
Published Germany 01.11.2005
Subjects
Adult
Female
Humans
Hypokalemia - complications
Hypokalemia - immunology
Kidney Diseases - complications
Kidney Diseases - immunology
Kidney Tubules - immunology
Kidney Tubules - pathology
Macrophages
Sjogren's Syndrome - complications
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Summary:We report a case of hypokalemic nephropathy associated with primary Sjögren's syndrome (SS). The patient presented with profound and persistent hypokalemia secondary to distal renal tubular acidosis (RTA). A renal biopsy exhibited tubular degeneration, marked interstitial fibrosis and intense macrophage infiltration. Hypokalemia has been reported to induce macrophage infiltration in experimental animal models but not in humans. This is the first report of intense tubulointerstitial macrophage infiltration in a patient with hypokalemic nephropathy associated with SS.
ISSN:0301-0430
DOI:10.5414/cnp64387