Nanoparticles: Oral Delivery for Protein and Peptide Drugs

Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and muco...

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Published inAAPS PharmSciTech Vol. 20; no. 5; p. 190
Main Authors Cao, Shu-jun, Xu, Shuo, Wang, Hui-ming, Ling, Yong, Dong, Jiahua, Xia, Rui-dong, Sun, Xiang-hong
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 20.05.2019
Subjects
Administration, Oral
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Drug Delivery Systems
Drug Design
Humans
Nanoparticles - administration & dosage
Peptides - administration & dosage
Pharmacology/Toxicology
Pharmacy
Proteins - administration & dosage
Review
Review Article
protein and peptide drugs
nanoparticles
bioavailability
oral delivery
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Abstract Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems. The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic.
AbstractList Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems. The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic.
Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems. The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic.Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems. The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic.
Author Xia, Rui-dong
Cao, Shu-jun
Ling, Yong
Dong, Jiahua
Wang, Hui-ming
Sun, Xiang-hong
Xu, Shuo
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Issue 5
Keywords protein and peptide drugs
nanoparticles
bioavailability
oral delivery
Language English
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Snippet Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for...
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SubjectTerms Administration, Oral
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Drug Delivery Systems
Drug Design
Humans
Nanoparticles - administration & dosage
Peptides - administration & dosage
Pharmacology/Toxicology
Pharmacy
Proteins - administration & dosage
Review
Review Article
Title Nanoparticles: Oral Delivery for Protein and Peptide Drugs
URI https://link.springer.com/article/10.1208/s12249-019-1325-z
https://www.ncbi.nlm.nih.gov/pubmed/31111296
https://www.proquest.com/docview/2232106580
https://pubmed.ncbi.nlm.nih.gov/PMC6527526
Volume 20
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