Nanoparticles: Oral Delivery for Protein and Peptide Drugs

Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and muco...

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Published inAAPS PharmSciTech Vol. 20; no. 5; p. 190
Main Authors Cao, Shu-jun, Xu, Shuo, Wang, Hui-ming, Ling, Yong, Dong, Jiahua, Xia, Rui-dong, Sun, Xiang-hong
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 20.05.2019
Subjects
Administration, Oral
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Drug Delivery Systems
Drug Design
Humans
Nanoparticles - administration & dosage
Peptides - administration & dosage
Pharmacology/Toxicology
Pharmacy
Proteins - administration & dosage
Review
Review Article
protein and peptide drugs
nanoparticles
bioavailability
oral delivery
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Summary:Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems. The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-019-1325-z