Benign epithelioid peripheral nerve sheath tumour resembling schwannoma

Peripheral nerve sheath tumours (PNST) with epithelial appearing cells compromise a heterogeneous group of neoplasms that are rare and diagnostically challenging. Of these, malignant PNSTs with epithelioid features (epithelioid MPNST) are commonly described in literature. However benign epithelioid...

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Published inMalaysian journal of pathology Vol. 36; no. 3; pp. 217 - 221
Main Authors Krishnamurthy, T, Niveditha, S R
Format Journal Article
LanguageEnglish
Published Malaysia College of Pathologists, Academy of Medicine of Malaysia 01.12.2014
Subjects
Biomarkers, Tumor
Biopsy
Diagnosis, Differential
Female
Humans
Neoplasms - diagnosis
Neoplasms - pathology
Nerve Sheath Neoplasms - diagnosis
Nerve Sheath Neoplasms - pathology
Neurilemmoma - diagnosis
Neurilemmoma - pathology
Young Adult
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Summary:Peripheral nerve sheath tumours (PNST) with epithelial appearing cells compromise a heterogeneous group of neoplasms that are rare and diagnostically challenging. Of these, malignant PNSTs with epithelioid features (epithelioid MPNST) are commonly described in literature. However benign epithelioid PNSTs are rare and till date about 38 cases have been described in the literature. We report a benign epithelioid PNST with light microscopical and immunohistochemical features suggestive of schwannoma, presenting as a thigh mass in a 23-year-old female. The tumour was encapsulated, showed epithelioid cells in aggregates, and expressed vimentin and S-100 positivity. There was no expression of CD34, CK, EMA, CD99, p63 and HMB 45. Typical Antoni A and Antoni B areas were absent. At 18 months follow-up, the patient was well.
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ISSN:0126-8635