Ecthyma gangrenosum in Saudi Arabia

We report a diagnosis of ecthyma gangrenosum EG in 4 females of mean age 54.8 range 43-64 years, within 10 months. Severe drug reaction treated with high dose systemic corticosteroids in patient one, acute myelocytic leukemia treated with high dose dexamethasone, and multiple broad-spectrum antibiot...

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Bibliographic Details
Published inSaudi medical journal Vol. 28; no. 11; p. 1741
Main Authors Obasi, Obasi E, Osoba, Abimbola O, Raddadi, Ali A
Format Journal Article
LanguageEnglish
Published Saudi Arabia 01.11.2007
Subjects
Adult
Anti-Bacterial Agents - therapeutic use
Biopsy
Diagnosis, Differential
Ecthyma - diagnosis
Ecthyma - drug therapy
Ecthyma - microbiology
Female
Gangrene
Humans
Middle Aged
Saudi Arabia
Saudi Arabia
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Summary:We report a diagnosis of ecthyma gangrenosum EG in 4 females of mean age 54.8 range 43-64 years, within 10 months. Severe drug reaction treated with high dose systemic corticosteroids in patient one, acute myelocytic leukemia treated with high dose dexamethasone, and multiple broad-spectrum antibiotics in patient 2 preceded the onset of EG. Patients 3 and 4 had vasculitic purpura and hemodialysis. In addition, patient 3 was receiving multiple broad-spectrum antibiotics plus anti-tuberculosis TB drugs for gastric TB, while patient 4 was on melphalan and high dose systemic corticosteroids. Pseudomonas aeruginosa was isolated from blood culture of the first 3 patients, and skin culture of patient one. Blister aspirate from patient 4 yielded Candida albicans. Factors enhancing skin invasion by pathogenic organisms in our patients were breached skin integrity, therapy with high dose corticosteroids and multiple broad-spectrum antibiotics, hematologic malignancies and chemotherapy with severe neutropenia.
ISSN:0379-5284