A rare neurological complication due to lithium poisoning

Lithium salts have been used in treatment of depression and bipolar disorder for more than 50 years. Neurotoxic side-effects such as nystagmus, ataxia, tremor, fasciculation, clonus, seizure and even coma have been well described in the literature. We present a case of generalised peripheral neuropa...

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Published inHong Kong medical journal = Xianggang yi xue za zhi Vol. 18; no. 4; pp. 343 - 345
Main Authors Chan, C H, Leung, Anne K H, Cheung, Y F, Chan, Phillip Y C, Yeung, K W Au, Lai, K Y
Format Journal Article
LanguageEnglish
Published China Hong Kong Academy of Medicine 01.08.2012
Subjects
Humans
Lithium Compounds - poisoning
Male
Middle Aged
Peripheral Nervous System Diseases - chemically induced
Peripheral Nervous System Diseases - diagnosis
Tomography, X-Ray Computed
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Summary:Lithium salts have been used in treatment of depression and bipolar disorder for more than 50 years. Neurotoxic side-effects such as nystagmus, ataxia, tremor, fasciculation, clonus, seizure and even coma have been well described in the literature. We present a case of generalised peripheral neuropathy following lithium intoxication. It is a rare presentation with delayed onset and characterised by a rapid downhill course. Diagnosis was confirmed by nerve conduction tests, which showed axonal neuropathy. Despite the profound neurological effects of this toxicity, it is readily reversible with supportive care and the prognosis is good.
Bibliography:ObjectType-Case Study-2
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ISSN:1024-2708
2226-8707