Peroxidasin: tying the collagen-sulfilimine knot

Type IV collagen, a major constituent of basement membranes, contains an unusual intermolecular sulfilimine crosslink whose route of biosynthesis has remained undefined. An oxidative triad consisting of peroxidasin, H(2)O(2) and halide is now shown to drive sulfilimine generation in vivo.

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Bibliographic Details
Published inNature chemical biology Vol. 8; no. 9; pp. 740 - 741
Main Author Weiss, Stephen J
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.09.2012
Subjects
Animals
Biosynthesis
Cellular biology
Collagen
Collagen Type IV - metabolism
Drosophila
Enzymes
Extracellular Matrix Proteins - metabolism
Imines - metabolism
Membranes
Oxidation-Reduction
Peroxidase - metabolism
Peroxidasin
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Summary:Type IV collagen, a major constituent of basement membranes, contains an unusual intermolecular sulfilimine crosslink whose route of biosynthesis has remained undefined. An oxidative triad consisting of peroxidasin, H(2)O(2) and halide is now shown to drive sulfilimine generation in vivo.
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SourceType-Scholarly Journals-1
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ISSN:1552-4450
1552-4469
DOI:10.1038/nchembio.1050