Ticagrelor Versus Clopidogrel in Patients With STEMI Treated With Fibrinolysis: TREAT Trial

• Published in: Journal of the American College of Cardiology Vol. 73; no. 22; pp. 2819 - 2828
• Main Authors: Berwanger, Otavio, Lopes, Renato D, Moia, Diogo D F, Fonseca, Francisco A, Jiang, Lixin, Goodman, Shaun G, Nicholls, Stephen J, Parkhomenko, Alexander, Averkov, Oleg, Tajer, Carlos, Malaga, Germán, Saraiva, Jose F K, Guimaraes, Helio P, de Barros E Silva, Pedro G M, Damiani, Lucas P, Santos, Renato H N, Paisani, Denise M, Miranda, Tamiris A, Valeis, Nanci, Piegas, Leopoldo S, Granger, Christopher B, White, Harvey D, Nicolau, Jose C
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 11.06.2019
• Subjects: Adjudication; Aged; Bleeding; Cardiology; Cardiovascular diseases; Cause of Death; Cerebral infarction; Clopidogrel; Clopidogrel - adverse effects; Clopidogrel - therapeutic use; Confidence intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Fibrin; Fibrinolysis; Heart attacks; Humans; Ischemia; Long-Term Care; Male; Middle Aged; Mortality; Myocardial infarction; Patients; Pharmacology; Randomization; ST Elevation Myocardial Infarction - drug therapy; ST Elevation Myocardial Infarction - mortality; Statistical analysis; Stroke; Studies; Survival Analysis; Therapy; Thrombolysis; Thrombolytic Therapy - methods; Ticagrelor - adverse effects; Ticagrelor - therapeutic use; Transient ischemic attack; Treatment Outcome; dual antiplatelet therapy; fibrinolysis; STEMI; ticagrelor; blinded adjudication; myocardial infarction
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2019.03.011

The efficacy of ticagrelor in the long-term post-ST-segment elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remains uncertain. The purpose of this study was to evaluate the efficacy of ticagrelor when compared with clopidogrel in STEMI patients treated with fibrinolytic therapy. This international, multicenter, randomized, open-label with blinded endpoint adjudication trial enrolled 3,799 patients (age <75 years) with STEMI receiving fibrinolytic therapy. Patients were randomized to ticagrelor (180-mg loading dose, 90 mg twice daily thereafter) or clopidogrel (300- to 600-mg loading dose, 75 mg daily thereafter). The key outcomes were cardiovascular mortality, myocardial infarction, or stroke, and the same composite outcome with the addition of severe recurrent ischemia, transient ischemic attack, or other arterial thrombotic events at 12 months. The combined outcome of cardiovascular mortality, myocardial infarction, or stroke occurred in 129 of 1,913 patients (6.7%) receiving ticagrelor and in 137 of 1,886 patients (7.3%) receiving clopidogrel (hazard ratio: 0.93; 95% confidence interval: 0.73 to 1.18; p = 0.53). The composite of cardiovascular mortality, myocardial infarction, stroke, severe recurrent ischemia, transient ischemic attack, or other arterial thrombotic events occurred in 153 of 1,913 patients (8.0%) treated with ticagrelor and in 171 of 1,886 patients (9.1%) receiving clopidogrel (hazard ratio: 0.88; 95% confidence interval: 0.71 to 1.09; p = 0.25). The rates of major, fatal, and intracranial bleeding were similar between the ticagrelor and clopidogrel groups. Among patients age <75 years with STEMI, administration of ticagrelor after fibrinolytic therapy did not significantly reduce the frequency of cardiovascular events when compared with clopidogrel. (Ticagrelor in Patients With ST Elevation Myocardial Infarction Treated With Pharmacological Thrombolysis [TREAT]; NCT02298088).