Nanocrystalline Epstein-Barr virus decoys

A novel biotechnology is introduced by way of the successful synthesis of nanocrystalline Epstein-Barr virus (EBV) decoys having specific in vivo immunogenic activity. Assembled from ultrafine surface modified tin oxide and purified DNA-free isolated EBV envelope proteins, the decoys consisted of le...

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Bibliographic Details
Published inJournal of applied biomaterials Vol. 2; no. 4; p. 251
Main Authors Kossovsky, N, Gelman, A, Sponsler, E, Millett, D
Format Journal Article
LanguageEnglish
Published United States 1991
Subjects
Animals
Antibodies, Viral - biosynthesis
Drug Carriers
Drug Evaluation, Preclinical
Herpesvirus 4, Human - immunology
Humans
Membrane Proteins
Particle Size
Rabbits
Surface Properties
Surface-Active Agents
Tin
Viral Envelope Proteins
Viral Vaccines
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Summary:A novel biotechnology is introduced by way of the successful synthesis of nanocrystalline Epstein-Barr virus (EBV) decoys having specific in vivo immunogenic activity. Assembled from ultrafine surface modified tin oxide and purified DNA-free isolated EBV envelope proteins, the decoys consisted of less than 150 nm units whose electrophoretic mobilities were similar to whole EBV; whose outer coats were strongly immunoreactive with murine monoclonal anti-EBV antibodies; and which elicited immunospecific neutralizing anti-EBV antibodies in the rabbit. The development of this carrier technology for vaccine preparations is suggested.
ISSN:1045-4861
DOI:10.1002/jab.770020406