A lipid emulsion reduces mortality from clomipramine overdose in rats

Tricyclic antidepressants are a common cause of self poisoning. Since these drugs are highly lipid soluble, we examined the interaction between imipramine and a lipid emulsion. Rats were given an iv dose of imipramine with either normal saline or a lipid emulsion as vehicle. The rats who received th...

Full description

Saved in:
Bibliographic Details
Published inVeterinary and human toxicology Vol. 44; no. 1; p. 30
Main Authors Yoav, Goor, Odelia, Goor, Shaltiel, Cabilil, Goor, Yoav, Goor, Odelia, Cabili, Shaltiel
Format Journal Article
LanguageEnglish
Published United States 01.02.2002
Subjects
Animals
Antidepressive Agents, Tricyclic - toxicity
Clomipramine - toxicity
Drug Overdose - drug therapy
Fat Emulsions, Intravenous - therapeutic use
Male
Rats
Rats, Wistar
Online AccessGet more information

Cover

More Information
Summary:Tricyclic antidepressants are a common cause of self poisoning. Since these drugs are highly lipid soluble, we examined the interaction between imipramine and a lipid emulsion. Rats were given an iv dose of imipramine with either normal saline or a lipid emulsion as vehicle. The rats who received the lipid emulsion had a significantly lower mortality. The role of lipid emulsions poisoning therapy is reviewed.
ISSN:0145-6296