Effect of monensin on Mayaro virus replication in monkey kidney and Aedes albopictus cells

The effect of a cationic ionophore, monensin, on the replication of Mayaro virus in monkey kidney TC7 and Aedes albopictus cells has been studied. Treatment of these cells with 1 micromol/l monensin during infection did not affect the virus protein synthesis but inhibited severely the virus replicat...

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Bibliographic Details
Published inActa virologica (Anglickâa verze) Vol. 47; no. 2; p. 113
Main Authors De Campos, R M, Ferreira, D F, Da Veiga, V F, Rebello, M A, Rebello, M C S
Format Journal Article
LanguageEnglish
Published Slovakia 2003
Subjects
Aedes - cytology
Alphavirus - drug effects
Alphavirus - physiology
Alphavirus - ultrastructure
Animals
Cell Line
Clone Cells - microbiology
Haplorhini
Kidney - cytology
Monensin - pharmacology
Viral Proteins - biosynthesis
Viral Proteins - drug effects
Virus Replication - drug effects
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Summary:The effect of a cationic ionophore, monensin, on the replication of Mayaro virus in monkey kidney TC7 and Aedes albopictus cells has been studied. Treatment of these cells with 1 micromol/l monensin during infection did not affect the virus protein synthesis but inhibited severely the virus replication. Electron microscopy of the cells infected with Mayaro virus and treated with monensin revealed that the morphogenesis of Mayaro virus was impaired in TC7 but not in A. albopictus cells.
ISSN:0001-723X