Ketoconazole-induced neurologic sequelae

A 77-y-old patient developed weakness of extremities, legs paralysis, dysarthria and tremor 1 h after ingestion of 200 mg ketoconazole for the first time in his life. All complaints faded away within 24 h. Few days later, the patient used another 200 mg ketoconazole tablet, and within an hour experi...

Full description

Saved in:
Bibliographic Details
Published inVeterinary and human toxicology Vol. 45; no. 5; p. 239
Main Authors Bulkowstein, Mordechai, Mordish, Yair, Zimmerman, Deena R, Sherman, Eliezer, Berkovitch, Matitiahu
Format Journal Article
LanguageEnglish
Published United States 01.10.2003
Subjects
Administration, Oral
Aged
Antifungal Agents - administration & dosage
Antifungal Agents - adverse effects
Candidiasis, Oral - drug therapy
Diagnosis, Differential
Humans
Ketoconazole - administration & dosage
Ketoconazole - adverse effects
Male
Paralysis - diagnosis
Paralysis - etiology
Tremor - diagnosis
Tremor - etiology
Online AccessGet more information

Cover

More Information
Summary:A 77-y-old patient developed weakness of extremities, legs paralysis, dysarthria and tremor 1 h after ingestion of 200 mg ketoconazole for the first time in his life. All complaints faded away within 24 h. Few days later, the patient used another 200 mg ketoconazole tablet, and within an hour experienced a similar clinical picture, which resolved again spontaneously within hours. Laboratory evaluations, including head CT scan, were normal. This case illustrates the need for close vigilance in adverse drug reactions, particularly in the elderly.
ISSN:0145-6296