Interferon-omega suppresses hepatitis B surface antigen production in human hepatoma cell line

Biological activities of human interferon (IFN) omega are less well characterized than those of other type I human IFNs. We compared the ability of recombinant IFN-omega, IFN-alpha 2 and IFN-gamma to inhibit the production of viral hepatitis B surface antigen (HBsAg) in the human hepatoma cell line...

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Bibliographic Details
Published inActa virologica (Anglickâa verze) Vol. 40; no. 4; p. 221
Main Authors Hajnická, V, Fuchsberger, N, Liptáková, H, Stancek, D, Kontsek, P
Format Journal Article
LanguageEnglish
Published Slovakia 01.09.1996
Subjects
Antiviral Agents - pharmacology
Carcinoma, Hepatocellular
Hepatitis B Surface Antigens - biosynthesis
Hepatitis B virus - drug effects
Humans
Interferon Type I - pharmacology
Tumor Cells, Cultured
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Summary:Biological activities of human interferon (IFN) omega are less well characterized than those of other type I human IFNs. We compared the ability of recombinant IFN-omega, IFN-alpha 2 and IFN-gamma to inhibit the production of viral hepatitis B surface antigen (HBsAg) in the human hepatoma cell line PLC/PRF/5. The results demonstrated that the capacity of IFN-omega to suppress the HBsAg synthesis was similar to that of IFN-alpha 2. The kinetics of the inhibitory effect of IFN-gamma differed from those of the two other IFNs.
ISSN:0001-723X