Reticulin antibodies: relationship with endocardium-vessel-interstitium antibodies and heterophilic antibodies

1. Indirect immunofluorescence was used to compare reticulin antibodies, endocardium-vessel-interstitium (EVI) antibodies and heterophilic antibodies in serum samples from patients with degenerative and inflammatory diseases, Chagas' disease, or paracoccidioidomycosis and from healthy blood don...

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Published inBrazilian journal of medical and biological research Vol. 23; no. 2; pp. 151 - 161
Main Authors Viero, R M, Chamma, L G, Franco, M
Format Journal Article
LanguageEnglish
Published Brazil 1990
Subjects
Animals
Antibodies - analysis
Antibodies, Heterophile - analysis
Blood Donors
Chagas Disease - immunology
Extracellular Space - immunology
Humans
Kidney - immunology
Mice
Myocardium - immunology
Paracoccidioidomycosis - immunology
Rats
Reticulin - immunology
Stomach - immunology
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Summary:1. Indirect immunofluorescence was used to compare reticulin antibodies, endocardium-vessel-interstitium (EVI) antibodies and heterophilic antibodies in serum samples from patients with degenerative and inflammatory diseases, Chagas' disease, or paracoccidioidomycosis and from healthy blood donors. 2. The antigen substrates used were rat, mouse and human liver for reticulin antibodies, mouse and human heart and skeletal muscle for EVI factor, and rat heart and rat, mouse and human kidney and stomach for heterophilic antibodies. 3. The three antibodies produced extremely similar fluorescent patterns and were present simultaneously in a large proportion of reticulin-positive serum samples. 4. The three antibodies were significantly absorbed by heterophilic antigens such as sheep and rat red blood cells and guinea pig kidney, by Trypanosoma cruzi (an antigen associated with EVI factor) and by Paracoccidioides brasiliensis. However, they did not react with several human tissues. 5. These results suggest that reticulin and EVI antibodies can be considered to be heterophilic antibodies.
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ISSN:0100-879X