Immunogenetics and clinical aspects of Takayasu's arteritis patients in a Mexican Mestizo population

• Published in: Clinical and experimental rheumatology Vol. 19; no. 4; pp. 439 - 443
• Main Authors: VARGAS-ALARCON, G, FLORES-DOMINGUEZ, C, HERNANDEZ-PACHECO, G, ZUNIGA, J, GAMBOA, R, SOTO, M. E, GRANADOS, J, REYES, P. A
• Format: Journal Article
• Language: English
• Published: Pisa Clinical and Experimental Rheumatology 01.07.2001
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; DNA - analysis; Ethnic Groups - genetics; Female; Gene Frequency; Histocompatibility Testing; HLA Antigens - genetics; Humans; Immunogenetics; Indians, North American - genetics; Male; Medical sciences; Mexico - epidemiology; Middle Aged; Odds Ratio; Polymerase Chain Reaction; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Takayasu Arteritis - ethnology; Takayasu Arteritis - genetics; Takayasu Arteritis - pathology; Central America; Mexico; America; Human; HLA-System; Pathogenesis; Major histocompatibility system; Cardiovascular disease; Exploration; Genetic determinism; Ethnic group; Vascular disease; Polymerase chain reaction; Symptomatology; Immunogenetics; Vasculitis; DNA; Admixture; Systemic disease; Genetics; Molecular biology; Takayashu arteritis
• ISSN: 0392-856X; 1593-098X

The aim of the present work was to study the association between HLA alleles and Takayasu's arteritis in Mexican Mestizo patients. The study included 26 Mexican Mestizo patients with Takayasu's arteritis and 99 healthy unrelated individuals. HLA-A, -B and -DR alleles were determined by polymerase chain reaction PCR-SSP RESULTS: Increased gene frequencies were demonstrated for HLA-B15(p=0.009,pC=0.020,OR=3.24,EF=11.9%) and HLA-B52 (p=0.008, pC=0.027, OR=5.16, EF=7.7%), and a decreased frequency for the HLA-A24 allele in patients compared to normal controls (p=0.035, pC=NS, PF=11.1%). When HLA typing was correlated to clinicalfeatures in 24 cases, wefound an increasedfrequencies of HLA-DR14 in patients with systemic arterial hypertension (p=0.005, pC=0.004, OR=24.6, EF=38.3%) and HLA-A2 on patients with pulmonary involvement (p=0.034, pC=0.036, OR=3.67, EF=40.4%) when compared to patients without these clinical manifestations. These data confirm HLA-B52 as a relevant susceptibility allele for Takayasu's arteritis and suggest that HLA-B15 could be important as a marker of the disease in Mexican patients. Other class I and/or class II alleles could also be relevant as markers for the clinical features present in these patients.