Sputum cytology for the diagnosis of lung cancer. Comparison of smear and modified cell block methods

• Published in: Acta cytologica Vol. 47; no. 6; p. 1023
• Main Authors: Erkiliç, Suna, Ozsaraç, Coşkun, Küllü, Sevgi
• Format: Journal Article
• Language: English
• Published: Switzerland 01.11.2003
• Subjects: Carcinoma, Bronchogenic - pathology; Coloring Agents - standards; Cytological Techniques - methods; Cytological Techniques - statistics & numerical data; Diagnostic Errors; Histocytological Preparation Techniques - methods; Histocytological Preparation Techniques - statistics & numerical data; Humans; Lung Neoplasms - pathology; Pathology, Surgical - methods; Predictive Value of Tests; Reproducibility of Results; Sputum - cytology
• ISSN: 0001-5547
• DOI: 10.1159/000326639

To compare the sputum smear cytology and cell block methods for specimen adequacy, cytology quality and diagnostic accuracy in the diagnosis of lung cancer. We assessed 2,524 sputum specimens from 768 patients. The specimens were prepared as smears and cell blocks for cytopathologic examination between March 1, 1992, and December 31, 1998. The smear and cell block slides were evaluated both separately and together, and the results were compared with radiologic and histopathologic diagnoses. The sensitivity of the smear method was 69.4% and specificity was 99.5%. The sensitivity of the cell block method was 84.4% and specificity, 100%. The sensitivity of the smear and cell block together was 87.6% and specificity, 99.5%. The cell block method increases the sensitivity and specificity of sputum cytology, and when smear and cell block slides are evaluated together, sensitivity reaches its highest value. Therefore, application of smear and cell block methods together seems most useful in the diagnosis of lung cancer.