The influence of the calcium channel antagonist verapamil on histamine release from target cells

The aim of the study was to investigate the influence of verapamil on anti-IgE induced histamine release from basophils isolated from the blood of 10 atopic asthma patients. The results of the investigations showed that verapamil in concentration of 10(-2)M - 10(-6)M significantly inhibits histamine...

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Bibliographic Details
Published inArchivum Immunologiae et Therapiae Experimentalis Vol. 37; no. 1-2; p. 55
Main Authors Hofman, J, Siergiejko, Z, Chyrek-Borowska, S
Format Journal Article
LanguageEnglish
Published Switzerland 1989
Subjects
Asthma - blood
Basophils - drug effects
Basophils - metabolism
Calcium Channel Blockers - pharmacology
Histamine - metabolism
Humans
Verapamil - pharmacology
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Summary:The aim of the study was to investigate the influence of verapamil on anti-IgE induced histamine release from basophils isolated from the blood of 10 atopic asthma patients. The results of the investigations showed that verapamil in concentration of 10(-2)M - 10(-6)M significantly inhibits histamine release from basophils of asthmatic patients. The degree of inhibition of histamine secretion depends on the concentration of the drug. Our studies suggest that verapamil may be useful in combination with more conventional drugs in the treatment of asthmatic patients, particularly those with ischemic heart diseases or hypertonia.
ISSN:0004-069X