Baroreflex failure: a neglected type of secondary hypertension
The arterial baroreflex buffers abrupt transients of blood pressure and prevents pressure from rising or falling excessively. In experimental animals, baroreceptor denervation results in temporary or permanent increases in blood pressure level and variability, depending on the extent of denervation....
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Published in | Netherlands journal of medicine Vol. 62; no. 5; pp. 151 - 155 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Alphen aan den Rijn
Van zuiden
01.05.2004
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Subjects | |
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Abstract | The arterial baroreflex buffers abrupt transients of blood pressure and prevents pressure from rising or falling excessively. In experimental animals, baroreceptor denervation results in temporary or permanent increases in blood pressure level and variability, depending on the extent of denervation. In humans, the clinical syndrome of baroreflex failure may arise from denervation of carotid baroreceptors following carotid body tumour resection, carotid artery surgery, neck irradiation and neck trauma. The syndrome is characterised by acute malignant hypertension and tachycardia followed by labile hypertension and hypotension. Baroreflex failure can be a cause of hypertension and should also be considered in the differential diagnosis of pheochromocytoma. Patients with suspected baroreflex failure should be referred to specialised centres for diagnostic testing and treatment. |
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AbstractList | The arterial baroreflex buffers abrupt transients of blood pressure and prevents pressure from rising or falling excessively. In experimental animals, baroreceptor denervation results in temporary or permanent increases in blood pressure level and variability, depending on the extent of denervation. In humans, the clinical syndrome of baroreflex failure may arise from denervation of carotid baroreceptors following carotid body tumour resection, carotid artery surgery, neck irradiation and neck trauma. The syndrome is characterised by acute malignant hypertension and tachycardia followed by labile hypertension and hypotension. Baroreflex failure can be a cause of hypertension and should also be considered in the differential diagnosis of pheochromocytoma. Patients with suspected baroreflex failure should be referred to specialised centres for diagnostic testing and treatment. |
Author | LENDERS, J. W. M KAREMAKER, J. M TIMMERS, H. J. L. M WIELING, W |
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Keywords | Hypertension Medicine Cardiovascular disease Secondary Baroreflex Failure |
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SubjectTerms | Animals Arterial hypertension. Arterial hypotension Baroreflex - physiology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Diagnosis, Differential General aspects Heart Rate Humans Hypertension - etiology Hypertension - physiopathology Hypertension - therapy Medical sciences |
Title | Baroreflex failure: a neglected type of secondary hypertension |
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