Baroreflex failure: a neglected type of secondary hypertension

The arterial baroreflex buffers abrupt transients of blood pressure and prevents pressure from rising or falling excessively. In experimental animals, baroreceptor denervation results in temporary or permanent increases in blood pressure level and variability, depending on the extent of denervation....

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Published inNetherlands journal of medicine Vol. 62; no. 5; pp. 151 - 155
Main Authors TIMMERS, H. J. L. M, WIELING, W, KAREMAKER, J. M, LENDERS, J. W. M
Format Journal Article
LanguageEnglish
Published Alphen aan den Rijn Van zuiden 01.05.2004
Subjects
Animals
Arterial hypertension. Arterial hypotension
Baroreflex - physiology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Diagnosis, Differential
General aspects
Heart Rate
Humans
Hypertension - etiology
Hypertension - physiopathology
Hypertension - therapy
Medical sciences
Hypertension
Medicine
Cardiovascular disease
Secondary
Baroreflex
Failure
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Summary:The arterial baroreflex buffers abrupt transients of blood pressure and prevents pressure from rising or falling excessively. In experimental animals, baroreceptor denervation results in temporary or permanent increases in blood pressure level and variability, depending on the extent of denervation. In humans, the clinical syndrome of baroreflex failure may arise from denervation of carotid baroreceptors following carotid body tumour resection, carotid artery surgery, neck irradiation and neck trauma. The syndrome is characterised by acute malignant hypertension and tachycardia followed by labile hypertension and hypotension. Baroreflex failure can be a cause of hypertension and should also be considered in the differential diagnosis of pheochromocytoma. Patients with suspected baroreflex failure should be referred to specialised centres for diagnostic testing and treatment.
Bibliography:ObjectType-Article-2
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ISSN:0300-2977
1872-9061