A role for gamma delta T lymphocytes in the development of advanced clinical forms of tuberculosis in HIV-infected patients

HIV patients frequently develop advanced pulmonary and extrapulmonary forms of tuberculosis. Although the main reasons seems to be the alteration of the CD4 super(+) alpha beta T cells, some groups have reported changes in the basal counts of gamma delta T cells. However, the potential implication o...

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Bibliographic Details
Published inAIDS (London) Vol. 11; no. 1; pp. 130 - 132
Main Authors Duarte, R, Ramírez, R, Kindelán, J M, Carracedo, J, Sanchez-Guijo, P
Format Journal Article
LanguageEnglish
Published England 01.01.1997
Subjects
AIDS/HIV
HIV Infections - immunology
human immunodeficiency virus
Humans
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Receptors, Antigen, T-Cell, gamma-delta - immunology
T-Lymphocytes - immunology
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Summary:HIV patients frequently develop advanced pulmonary and extrapulmonary forms of tuberculosis. Although the main reasons seems to be the alteration of the CD4 super(+) alpha beta T cells, some groups have reported changes in the basal counts of gamma delta T cells. However, the potential implication of an impaired delta sub(2) response to M. tuberculosis in HIV patients is unknown, and hence the objective of our study was to investigate this response.
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ISSN:0269-9370