Histological types of nasopharyngeal carcinoma as compared to EBV serology

One hundred and thirteen cases of nasopharyngeal carcinoma (NPC) were classified histologically according to the WHO-, French and Cologne systems. The various histological tumor types were then correlated with data on Epstein-Barr virus (EBV) serology (EA, VCA, EBNA, CF, IgA-VCA). The results showed...

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Bibliographic Details
Published inAnticancer research Vol. 1; no. 4; p. 187
Main Authors Krueger, G R, Kottaridis, S D, Wolf, H, Ablashi, D V, Sesterhenn, K, Bertram, G
Format Journal Article
LanguageEnglish
Published Greece 1981
Subjects
Antibodies, Viral - analysis
Carcinoma - classification
Carcinoma - immunology
Carcinoma - pathology
Herpesvirus 4, Human - immunology
Humans
Nasopharyngeal Neoplasms - classification
Nasopharyngeal Neoplasms - immunology
Nasopharyngeal Neoplasms - pathology
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Summary:One hundred and thirteen cases of nasopharyngeal carcinoma (NPC) were classified histologically according to the WHO-, French and Cologne systems. The various histological tumor types were then correlated with data on Epstein-Barr virus (EBV) serology (EA, VCA, EBNA, CF, IgA-VCA). The results showed non-keratinizing carcinomas with lymphoid infiltration, and undifferentiated carcinomas to be associated with significantly elevated anti-EBV titers. These two tumor types can be easily grouped together according to the French classification scheme as "undifferentiated carcinoma of the nasopharyngeal type (UCNT)". Such a procedure, which may have therapeutic implication, simplifies the rapid diagnostic screening of NPC patients and also may enhance the reproducibility of histological tumor typing.
ISSN:0250-7005