Antibacterial activity of primycin against multiple strains of gram-positive bacteria

Crystalline primycin was found to be very active in broth dilution assay against Staphylococcus aureus (50 strains), Staphylococcus epidermidis (77 strains), Streptococcus faecalis (76 strains) and one strain of Listeria monocytogenes with minimal inhibitory concentrations (MIC) of 0.12-0.5 microgra...

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Bibliographic Details
Published inActa microbiologica Hungarica Vol. 33; no. 2; p. 141
Main Author Uri, J V
Format Journal Article
LanguageEnglish
Published Hungary 1986
Subjects
Anti-Bacterial Agents - pharmacology
Bacillus subtilis - drug effects
Culture Media
Enterococcus faecalis - drug effects
Gram-Positive Bacteria - drug effects
Hydrogen-Ion Concentration
Lactones - pharmacology
Listeria monocytogenes - drug effects
Macrolides
Microbial Sensitivity Tests
Staphylococcus aureus - drug effects
Staphylococcus epidermidis - drug effects
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Summary:Crystalline primycin was found to be very active in broth dilution assay against Staphylococcus aureus (50 strains), Staphylococcus epidermidis (77 strains), Streptococcus faecalis (76 strains) and one strain of Listeria monocytogenes with minimal inhibitory concentrations (MIC) of 0.12-0.5 microgram/ml. The activity was influenced by the pH of the liquid medium with greater activity (lower MICs) at pH 8 against the majority of strains, than at pH 6 or 7.3. In disc agar diffusion assay Bacillus subtilis ATCC 6633 proved more sensitive than staphylococcus strains.
ISSN:0231-4622