Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon

With the use of viral vectors harboring myc and src oncogenes, we have assessed the potential contribution of these different elements to colonic neoplasia using a transplantation technique resulting in the formation of a heterotopic colon in Wistar Furth rats. While myc alone induced atypia and som...

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Bibliographic Details
Published inOncogene Vol. 6; no. 2; p. 303
Main Authors D'Emilia, J C, Mathey-Prevot, B, Jaros, K, Wolf, B, Steele, Jr, G, Summerhayes, I C
Format Journal Article
LanguageEnglish
Published England 01.02.1991
Subjects
Animals
Colon - pathology
Colonic Neoplasms - etiology
Colonic Neoplasms - pathology
Genes, myc
Genes, src
Phenotype
Precancerous Conditions - etiology
Precancerous Conditions - pathology
Rats
Rats, Inbred Strains
Retroviridae - genetics
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Summary:With the use of viral vectors harboring myc and src oncogenes, we have assessed the potential contribution of these different elements to colonic neoplasia using a transplantation technique resulting in the formation of a heterotopic colon in Wistar Furth rats. While myc alone induced atypia and some dysplasia, src induced focal dysplastic lesions throughout the colon mucosa with evidence of metaplasia. In contrast, lesions induced by myc and src acting cooperatively, were highly dysplastic with evidence of tumor formation after protracted periods. These results indicated the formation of histologically distinct preneoplastic lesions elicited by the action of a single oncogene in colon implants with the production of adenocarcinomas when such oncogenic elements act cooperatively. This model provides an opportunity for studies of the action of different oncogenes, acting singly or in combination, in the multi-step progression to colon tumor formation.
ISSN:0950-9232
1476-5594