Effects of inhalation of red phosphorus/butyl rubber combustion products on aveolar macrophage responses in rats

The effects of inhalation of red phosphorus/butyl rubber (RP/BR) used as an obscurant smoke in tactical environments was examined. Sprague-Dawley male rats were exposed to 1000 mg/m3 of RP/BR for 3.5 h in single exposures, while in subsequent intermediate and subchronic studies the animals were expo...

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Bibliographic Details
Published inJournal of applied toxicology Vol. 8; no. 6; p. 393
Main Authors Aranyi, C, Vana, S N, Bradof, J N, Sherwood, R
Format Journal Article
LanguageEnglish
Published England 01.12.1988
Subjects
5'-Nucleotidase
Adenosine Triphosphate - analysis
Administration, Inhalation
Animals
Bronchi - pathology
Cell Count - drug effects
Elastomers
Fibrosis
Klebsiella pneumoniae - immunology
Macrophages - drug effects
Macrophages - immunology
Male
Nucleotidases - analysis
Phagocytosis - drug effects
Phosphorus - toxicity
Pulmonary Alveoli - drug effects
Pulmonary Alveoli - enzymology
Pulmonary Alveoli - immunology
Rats
Rats, Inbred Strains
Rubber - toxicity
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Summary:The effects of inhalation of red phosphorus/butyl rubber (RP/BR) used as an obscurant smoke in tactical environments was examined. Sprague-Dawley male rats were exposed to 1000 mg/m3 of RP/BR for 3.5 h in single exposures, while in subsequent intermediate and subchronic studies the animals were exposed to concentrations ranging from 300 to 1200 mg/m3 for 2.25 h/day, 4 consecutive days/week for 4 and 13 weeks, respectively. Pulmonary bactericidal activity to inhaled [35S]-Klebsiella pneumoniae was depressed after the acute and the 13-week subchronic exposures but was unchanged after the 4-week exposures. The pulmonary free cells collected by lavage showed decreasing trends in total numbers, increased ATP levels and decreased ectoenzyme activity for 5'-nucleotidase after most of the exposures. Mild-to-moderate-to-severe terminal broncheolar fibrosis was observed in all rats after 4- and 13-week exposures to greater than or equal to 750 mg/m3 of RP/BR. The severity of the lesions increased with the severity of the exposure conditions. Except for the fibrosis, most changes were reversible.
ISSN:0260-437X