HLA antigen profiles in Thai tuberculosis patients

HLA antigens were studied in 35 Thai patients suffering from active pulmonary tuberculosis. An increase in the frequency of HLA-Bw46 and -DR4 and a decrease in the frequency of HLA-B12 were found when compared with the matched controls. These findings suggest that the pathogenetic role of HLA-B12 is...

Full description

Saved in:
Bibliographic Details
Published inAsian Pacific journal of allergy and immunology Vol. 6; no. 2; p. 77
Main Authors Chandanayingyong, D, Maranetra, N, Bovornkitti, S
Format Journal Article
LanguageEnglish
Published Thailand 01.12.1988
Subjects
Adolescent
Adult
Aged
HLA Antigens - analysis
HLA Antigens - classification
Humans
Middle Aged
Thailand
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - ethnology
Tuberculosis, Pulmonary - genetics
Tuberculosis, Pulmonary - immunology
Thailand
Online AccessGet more information

Cover

More Information
Summary:HLA antigens were studied in 35 Thai patients suffering from active pulmonary tuberculosis. An increase in the frequency of HLA-Bw46 and -DR4 and a decrease in the frequency of HLA-B12 were found when compared with the matched controls. These findings suggest that the pathogenetic role of HLA-B12 is to confer resistance and that HLA-Bw46 and -DR4 are associated with susceptibility. In addition it provided further information on HLA antigen profiles in pulmonary tuberculosis patients in another ethnic group (viz. Thais). Conclusions regarding genetic control over therapeutic efficacy must await further study.
ISSN:0125-877X