Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation: Attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin

• Published in: Diabetes (New York, N.Y.) Vol. 51; no. 8; pp. 2648 - 2652
• Main Authors: CHRIST, Michael, BAUERSACHS, Johann, LIEBETRAU, Claudia, HECK, Marina, GÜNTHER, Andreas, WEHLING, Martin
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.08.2002
• Subjects: Animals; Associated diseases and complications; Atorvastatin; Biological and medical sciences; Coronary Vessels - drug effects; Coronary Vessels - enzymology; Coronary Vessels - physiology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Endothelium, Vascular - drug effects; Endothelium, Vascular - enzymology; Endothelium, Vascular - physiology; Enzyme Activation - drug effects; Glucose - pharmacology; Heptanoic Acids - pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; In Vitro Techniques; Medical sciences; Mevalonic Acid - pharmacology; NADH, NADPH Oxidoreductases - metabolism; NADPH Oxidases; Pyrroles - pharmacology; Superoxides - metabolism; Swine; Endocrinopathy; Diabetes mellitus; Coronary artery; Cardiovascular disease; Glucose; Coenzyme; Endothelium; Vascular disease; NAD; Hyperoxides; Atherosclerosis; Atorvastatin; Complication

Increased vascular superoxide anion (O(2)(-)) formation is essentially involved in the pathophysiology of atherosclerosis. Chronic hyperglycemia induces endothelial dysfunction, probably due to increased formation of reactive oxygen intermediates. However, little is known about the localization, mod...