Effect of sodium nitroprusside on hemodynamics of corpus cavernosum in Chinese

• Published in: Asian journal of andrology Vol. 3; no. 4; pp. 311 - 313
• Main Authors: FU, Qiang, YAO, De-Hong, JIANG, Yue-Qing
• Format: Journal Article
• Language: English
• Published: Oxford blackwell 01.12.2001
• Subjects: Adult; Aged; Associated diseases and complications; Biological and medical sciences; China; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Erectile Dysfunction - drug therapy; Erectile Dysfunction - physiopathology; Fundamental and applied biological sciences. Psychology; Hemodynamics - drug effects; Hormone metabolism and regulation; Humans; Male; Mammalian male genital system; Medical sciences; Middle Aged; Nitric Oxide Donors - administration & dosage; Nitric Oxide Donors - pharmacology; Nitroprusside - administration & dosage; Nitroprusside - pharmacology; Penile Erection - drug effects; Testis - blood supply; Testis - diagnostic imaging; Testis - drug effects; Ultrasonography, Doppler; Vertebrates: reproduction
• ISSN: 1008-682X; 1745-7262

To study the effect of sodium nitroprusside (SNP) on the hemodynamics of corpus cavernosum in Chinese men with erectile dysfunction (ED). In 68 ED patients receiving intracavernous injection (ICI) of SNP, the cavernous hemodynamics were studied by Doppler ultrasonography. The peak flow velocity (PFV), the artery diameter (Ad), the mean velocity of arterial blood (MV) and the vein diameter (Vd) were significantly higher after ICI of SNP than before ICI, but the end diastolic velocity (EDV) did not change significantly. The increase in Vd after SNP suggests that the venous outflow is not invariably decreased during penile erection.