Changes of morphological, biological and antigenic properties of avian influenza A virus haemagglutinin H2 in the course of adaptation to new host

The alterations of avian influenza A virus haemagglutinin (HA) H2 as a result of adaptation to mice were first investigated in this study. HA of mouse-adapted (MA) variant was somewhat different from that of the original strain in electrophoretical mobility, antigenic structure and in haemagglutinat...

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Bibliographic Details
Published inActa virologica (Anglickâa verze) Vol. 39; no. 5-6; p. 279
Main Authors Lipatov, A S, Gitelman, A K, Govorkova, E A, Smirnov YuA
Format Journal Article
LanguageEnglish
Published Slovakia 01.12.1995
Subjects
Adaptation, Physiological
Animals
Birds
Cell Line
Chick Embryo
Dogs
Electrophoresis, Polyacrylamide Gel
Erythrocytes - immunology
Hemagglutination Tests
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral - chemistry
Hemagglutinins, Viral - immunology
Influenza A virus - immunology
Influenza in Birds - immunology
Influenza in Birds - virology
Mice
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - virology
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Summary:The alterations of avian influenza A virus haemagglutinin (HA) H2 as a result of adaptation to mice were first investigated in this study. HA of mouse-adapted (MA) variant was somewhat different from that of the original strain in electrophoretical mobility, antigenic structure and in haemagglutination activity with mouse red blood cells.
ISSN:0001-723X