Structural analysis of c-myc in human sporadic colorectal carcinomas

Analysis of the DNA extracted from the colonic mucosa of 13 patients operated for colorectal carcinoma revealed c-myc rearrangements in three of them. In all cases, the alterations were found both in the histologically normal and in the tumoral mucosa. In one case, a different pattern of rearrangeme...

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Bibliographic Details
Published inAnticancer research Vol. 14; no. 3A; p. 1103
Main Authors Albanese, I, Alberti, M, Bazan, V, Russo, A, Baiamonte, S, Migliavacca, M, Bazan, P, La Farina, M
Format Journal Article
LanguageEnglish
Published Greece 01.05.1994
Subjects
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms - genetics
Female
Gene Rearrangement
Genes, myc
Humans
Intestinal Mucosa - chemistry
Male
Middle Aged
Prospective Studies
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Summary:Analysis of the DNA extracted from the colonic mucosa of 13 patients operated for colorectal carcinoma revealed c-myc rearrangements in three of them. In all cases, the alterations were found both in the histologically normal and in the tumoral mucosa. In one case, a different pattern of rearrangements characterized the two tissues. In all three individuals, the c-myc sequences appeared to be amplified. We suggest that c-myc rearrangements in the histologically normal colonic mucosa of colorectal carcinoma patients could represent a predisposition factor for the development of additional neoplasms.
ISSN:0250-7005