Pronuclear scoring. Time for international standardization

Zygote scoring is an efficient tool for embryo selection not only in countries where embryo selection is not permitted. Several different scoring systems have been published so far, making comparisons of assessments between investigators and laboratories extremely difficult. Pronuclear evaluation sh...

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Bibliographic Details
Published inJournal of reproductive medicine Vol. 48; no. 5; p. 365
Main Authors Zollner, Ursula, Zollner, Klaus-Peter, Steck, Thomas, Dietl, Johannes
Format Journal Article
LanguageEnglish
Published United States 01.05.2003
Subjects
Adult
Decision Making
Embryonic and Fetal Development
Female
Fertilization in Vitro
Humans
International Cooperation
Pregnancy
Reference Values
World Health Organization
Zygote - classification
Zygote Intrafallopian Transfer
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Summary:Zygote scoring is an efficient tool for embryo selection not only in countries where embryo selection is not permitted. Several different scoring systems have been published so far, making comparisons of assessments between investigators and laboratories extremely difficult. Pronuclear evaluation should be standardized in a manner analogous to the standardization of cleavage stage embryo scoring or of semen evaluation by the World Health Organization. The ideal score should be clear and easily applicable. The items that have the greatest influence on embryonic development seem to be alignment and size of pronuclei, alignment and number of nucleoli, halo effect and appearance of vacuoles. These morphologic parameters can be observed in different features and can be summarized as a zygote score.
ISSN:0024-7758