Erythrocyte superoxide dismutase activity differs in clinical subgroups of Parkinson's disease patients

There is controversy as to whether there are clinical subgroups in Parkinson's disease (PD). Six tremor-dominant and six bradykinesia-dominant patients identified among 29 cases with PD were compared in terms of erythrocyte superoxide dismutase (SOD) activity and several clinical variables. Ery...

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Bibliographic Details
Published inActa neurologica Belgica Vol. 101; no. 3; p. 180
Main Authors Akbostanci, M C, Kocatürk, P A, Tan, F U, Kavas, G O
Format Journal Article
LanguageEnglish
Published Italy 01.09.2001
Subjects
Adult
Age of Onset
Aged
Antiparkinson Agents - adverse effects
Dose-Response Relationship, Drug
Erythrocytes - enzymology
Female
Humans
Hypokinesia - blood
Hypokinesia - enzymology
Hypokinesia - etiology
Male
Middle Aged
Parkinson Disease - blood
Parkinson Disease - classification
Parkinson Disease - enzymology
Sex Factors
Superoxide Dismutase - blood
Tremor - blood
Tremor - enzymology
Tremor - etiology
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Summary:There is controversy as to whether there are clinical subgroups in Parkinson's disease (PD). Six tremor-dominant and six bradykinesia-dominant patients identified among 29 cases with PD were compared in terms of erythrocyte superoxide dismutase (SOD) activity and several clinical variables. Erythrocyte SOD activity in tremor-dominant patients was higher than in bradykinesia-dominant patients. According to our preliminary results obtained from small number of patients, the difference of SOD activity in clinically distinct subgroups suggests there may be separate clinical subgroups of PD which can be differentiated by a biological marker.
ISSN:0300-9009
2240-2993