Fourier transform-infrared microspectroscopy and microscopic imaging

For age- and sex-matched subjects, osteoporotic bone is more fragile than healthy bone. Vibrational infrared spectroscopy and in particular infrared microspectroscopic imaging is a useful tool for investigating and characterizing changes associated with metabolic bone diseases including osteoporosis...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 455; p. 293
Main Authors Gourion-Arsiquaud, Samuel, West, Paul A, Boskey, Adele L
Format Journal Article
LanguageEnglish
Published United States 2008
Subjects
Bone and Bones - chemistry
Bone and Bones - pathology
Humans
Microspectrophotometry - instrumentation
Microspectrophotometry - methods
Osteoporosis - pathology
Spectroscopy, Fourier Transform Infrared - instrumentation
Spectroscopy, Fourier Transform Infrared - methods
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Summary:For age- and sex-matched subjects, osteoporotic bone is more fragile than healthy bone. Vibrational infrared spectroscopy and in particular infrared microspectroscopic imaging is a useful tool for investigating and characterizing changes associated with metabolic bone diseases including osteoporosis in biopsied tissues. Strength-related measures such as bone mineral content/composition as well as spectroscopically determined bone quality-related measures such as mineral crystallinity, carbonate substitution, and collagen cross-linking consequently differ between osteoporotic patients and normal subjects. Validated IR parameters specific to the mineral and matrix components of bone have been defined and can now be used to quantify anatomical/spatial variations and the effect of new therapies on osteoporotic bone.
ISSN:1064-3745
DOI:10.1007/978-1-59745-104-8_20