Blood cell kinetics after a 385 cGy total body irradiation given to a CML patient for bone marrow transplantation

Fractionated total body irradiation was given to a patient with chronic myeloid leukemia as part of a conditioning regimen for bone marrow transplantation. The radiation treatment was discontinued after the third fraction (total dose: 385 cGy) and no bone marrow graft was given because of the patien...

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Bibliographic Details
Published inBone marrow transplantation (Basingstoke) Vol. 7; no. 4; pp. 317 - 320
Main Authors GIRINSKY, T, BAUME, D, SOCIE, G, PICO, J. L, MALAISE, E, COSSET, J. M
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.04.1991
Subjects
Adult
Biological and medical sciences
Blood Cell Count - radiation effects
Bone Marrow - pathology
Bone Marrow - radiation effects
Bone Marrow Transplantation
Female
Hematopoiesis - radiation effects
Hemopathies
Humans
Kinetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - physiopathology
Lymphocyte Subsets - radiation effects
Medical sciences
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Whole-Body Irradiation - adverse effects
Human
Low dose
Malignant hemopathy
Radiotherapy
Cell subpopulation
Case study
Myeloproliferative syndrome
Treatment
Cell cycle
Chronic myelocytic leukemia
T-Lymphocyte
Adult
Whole body
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Summary:Fractionated total body irradiation was given to a patient with chronic myeloid leukemia as part of a conditioning regimen for bone marrow transplantation. The radiation treatment was discontinued after the third fraction (total dose: 385 cGy) and no bone marrow graft was given because of the patient's refusal. Peripheral blood lymphocyte levels were monitored for 3 months and lymphocyte subsets up to 50 days post-irradiation. Lymphocyte numbers reached the nadir 48 h after the last fraction and lymphopenia was still present 3 months later. All lymphocyte subsets (T, B, CD4 and CD8 cells) showed a similar decrease except for natural killer cells which exhibited a larger decline. The regenerative capacity of T cells, CD4 subset and natural killer cells was less than that of B cells and CD8 lymphocyte subsets.
ISSN:0268-3369
1476-5365