Potential role of heparin in prevention of liver metastasis from colon cancer

The case of a 59 year-old man with sigmoid colon cancer and synchronous liver metastases is described in this report. Sigmoid colectomy and partial hepatectomy were performed, and hepatic arterial cannulation was done for prevention of hepatic recurrence. Heparin was injected to prevent catheter-rel...

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Bibliographic Details
Published inHepato-gastroenterology Vol. 46; no. 30; p. 3241
Main Authors Aramaki, M, Kawano, K, Sasaki, A, Ohno, T, Tahara, K, Takeuchi, Y, Yoshida, T, Kitano, S
Format Journal Article
LanguageEnglish
Published Greece 01.11.1999
Subjects
Adenocarcinoma - diagnosis
Adenocarcinoma - prevention & control
Adenocarcinoma - secondary
Biopsy
Colectomy
Fibrinolytic Agents - therapeutic use
Heparin - therapeutic use
Hepatectomy
Humans
Liver Neoplasms - diagnosis
Liver Neoplasms - prevention & control
Liver Neoplasms - secondary
Male
Middle Aged
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - prevention & control
Sigmoid Neoplasms - diagnostic imaging
Sigmoid Neoplasms - pathology
Sigmoid Neoplasms - surgery
Sigmoidoscopy
Tomography, X-Ray Computed
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Summary:The case of a 59 year-old man with sigmoid colon cancer and synchronous liver metastases is described in this report. Sigmoid colectomy and partial hepatectomy were performed, and hepatic arterial cannulation was done for prevention of hepatic recurrence. Heparin was injected to prevent catheter-related clots, and no anticancer drugs were used. He did well without signs of recurrence for 5 years after the initial operation. After we stopped the heparin administration, recurrence was detected in the liver. The patient underwent repeat hepatectomy, and he is now doing well without recurrence 2 years after the second operation. The clinical course of this case suggests that heparin may prevent liver metastasis of colorectal cancer.
ISSN:0172-6390