Increased serum levels of vascular endothelial growth factor in human crescentic glomerulonephritis

• Published in: Clinical nephrology Vol. 52; no. 2; p. 76
• Main Authors: Nitta, K, Uchida, K, Kimata, N, Honda, K, Horita, S, Hayashi, T, Ishizuka, T, Kobayashi, H, Kawashima, A, Yumura, W, Nihei, H
• Format: Journal Article
• Language: English
• Published: Germany 01.08.1999
• Subjects: Adrenal Cortex Hormones - therapeutic use; Adult; Aged; Analysis of Variance; Creatinine - blood; Endothelial Growth Factors - blood; Enzyme-Linked Immunosorbent Assay; Female; Glomerulonephritis - blood; Glomerulonephritis - classification; Glomerulonephritis - drug therapy; Glomerulonephritis - pathology; Glomerulonephritis, IGA - blood; Glomerulosclerosis, Focal Segmental - blood; Humans; Kidney Glomerulus - pathology; Lymphokines - blood; Macrophages - pathology; Male; Middle Aged; Nephritis - blood; Nephritis - etiology; Nephrosis, Lipoid - blood; Protein Isoforms - blood; Purpura, Schoenlein-Henoch - complications; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors
• ISSN: 0301-0430

To investigate the serum levels of vascular endothelial growth factor (VEGF) in human crescentic glomerulonephritis (CRGN). The serum VEGF levels in CRGN patients were compared with those in healthy subjects and in various types of glomerulonephritis. In addition, we investigated the relationship between serum VEGF levels and creatinine levels (Scr) and pathological parameters. The serum VEGF levels of the CRGN patients were significantly higher than in the healthy subjects and patients with MCNS, IgAN, and FGS. No correlation was found between serum VEGF levels and Scr in the RPGN patients. The serum VEGF levels in 6 CRGN patients had significantly decreased after 6 months of corticosteroid therapy. Moreover, there was a significant correlation between the serum VEGF levels and the crescent frequency or the grade of interstitial injury, and the rates of glomerular infiltration by macrophages. In the CRGN patients, severe glomerular and interstitial damages would result in increased serum VEGF levels and corticosteroid therapy may exert its efficacy through reduction of serum VEGF levels.