Clinicopathological study of myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

• Published in: Clinical nephrology Vol. 52; no. 5; p. 293
• Main Authors: Yorioka, N, Taniguchi, Y, Amimoto, D, Ogata, S, Sakikubo, E, Yamakido, M, Naito, T, Shimamoto, F
• Format: Journal Article
• Language: English
• Published: Germany 01.11.1999
• Subjects: Adult; Aged; Aged, 80 and over; Antibodies, Antineutrophil Cytoplasmic - analysis; Creatinine - blood; Female; Glomerulonephritis - immunology; Glomerulonephritis - metabolism; Glomerulonephritis - pathology; Glomerulonephritis - therapy; Humans; Kidney Glomerulus - pathology; Male; Middle Aged; Peroxidase - immunology; Prognosis; Proteinuria; Serum Albumin - analysis; Treatment Outcome
• ISSN: 0301-0430

To investigate the potential prognostic factors for myeloperoxidase anti-neutrophil cytoplasmic antibody- (MPO-ANCA) associated glomerulonephritis. The clinical and pathological findings were reviewed in 17 patients with this type of glomerulonephritis. The relationship between the outcome and various clinical and pathological factors were assessed. The relationship between the blood MPO-ANCA level and cellular crescent formation was also investigated. Patients who died had a significantly lower serum albumin and creatinine clearance than those who survived, but there were no differences of age, blood MPO-ANCA, urinary protein, and serum creatinine levels or cellular crescent formation between the two groups. There was a close relationship between blood MPO-ANCA levels and cellular crescent formation. Hypoalbuminemia and renal dysfunction may be indicators of a poor prognosis in MPO-ANCA-associated glomerulonephritis. Patients with high blood levels of this antibody and increased cellular crescent formation appear to have active disease, but these factors are not statistically associated with a fatal outcome. Therefore, aggressive treatment may be indicated in patients with active disease initially.