Comparison of Tc-99m sestamibi, serum neuron-specific enolase and lactate dehydrogenase as predictors of response to chemotherapy in small cell lung cancer

• Published in: Cancer biotherapy & radiopharmaceuticals Vol. 15; no. 4; pp. 381 - 386
• Main Authors: LIM, Sung-Chul, PARK, Kyung-Ok, KIM, Young-Chul, NA, Kook-Joo, HOCHEON SONG, BOM, Hee-Seung
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Larchmont, NY Liebert 01.08.2000
• Subjects: Aged; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Biomarkers, Tumor - blood; Carcinoma, Small Cell - blood; Carcinoma, Small Cell - diagnostic imaging; Carcinoma, Small Cell - drug therapy; Chemotherapy; Dipyridamole - administration & dosage; Female; Humans; L-Lactate Dehydrogenase - blood; Lung Neoplasms - blood; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - drug therapy; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Phosphopyruvate Hydratase - blood; Predictive Value of Tests; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Antineoplastic agent; Intravenous administration; Lyases; Tumoral marker; Bronchopulmonary; Bronchus disease; Radiopharmaceuticals; Small cell carcinoma; Labelled compound; Phosphopyruvate hydratase; Platinum II Complexes; Human; Lung disease; Respiratory disease; Enzyme; Dipyridamole; Prediction; Etoposide; Malignant tumor; Cisplatin; L-Lactate dehydrogenase; Podophyllotoxine derivatives; Chemotherapy; Treatment; Computerized axial tomography; Oxidoreductases; Carbon-oxygen lyases; Technetium(99mTc) sestamibi; Hydro-lyases
• ISSN: 1084-9785; 1557-8852
• DOI: 10.1089/cbr.2000.15.381

Neuron-specific enolase (NSE) and lactate dehydrogenase (LDH) are tumor markers of small cell lung cancer (SCLC) which were reported to predict outcome of patients with SCLC. We previously reported that dipyridamole-modulated Tc-99m sestamibi (dipyridamole-MIBI) single photon emission computed tomography (SPECT) could predict the response to chemotherapy in SCLC patients. The purpose of this study was to compare dipyridamole-MIBI and pretreatment serum levels of NSE and LDH for the prediction of response to chemotherapy in SCLC. Twenty-eight SCLC patients underwent dipyridamole-MIBI SPECT 3 to 7 days before starting chemotherapy (80 mg/m2 etoposide and 80 mg/m2 cisplatin every 3 or 4 weeks for at lease two cycles). Serum levels of NSE and LDH were also measured at the same day of the imaging. Tomographic images before and after 0.84 mg/kg dipyridamole infusion were acquired 1 hour after injection of 370 (10 mCi) and 1,110 (30 mCi) MBq MIBI, respectively. The response to chemotherapy was grouped as specified as complete (CR), partial response (PR), no change (NC), and progressive disease (PD), according to the change in tumor size on chest roentgenography and CT. Patients showing CR and PR were classified as responders, and those who showed NC and PD were considered nonresponders. Among the 28 patients, 15 were responders (2 CR, 13 PR) and 13 were nonresponders (11 NC, 2 PD). The change of tumor-to-normal lung ratio (T:NL) after infusion of dipyridamole was significantly higher in responders as compared with nonresponders (0.38 +/- 0.64 vs. -0.38 +/- 0.50, respectively, p = 0.002). However, pretreatment serum NSE and LDH levels did not correlate with the response to chemotherapy. Increase of T:NL after dipyridamole infusion was a strong negative predictor of chemotherapeutic response in SCLC patients, while NSE and LDH could not predict it.