Effects of alpha-interferon on iron-related measurements in human subjects

Subcutaneous administration of alpha-interferon to normal volunteers caused hypoferraemia and hyperferritinaemia. There was, however, no concomitant rise in other components of the acute-phase response, including the serum C-reactive protein value, the granulocyte count and the plasma lactoferrin co...

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Published inSouth African medical journal Vol. 78; no. 11; pp. 627 - 628
Main Authors BAYNES, R. D, BEZWODA, W. R, DAJEE, D, LAMPARELLI, R. D, BOTHWELL, T. H
Format Journal Article
LanguageEnglish
Published Pinelands Medical Association of South Africa 01.12.1990
Subjects
Biological and medical sciences
C-Reactive Protein - analysis
Drug toxicity and drugs side effects treatment
Ferritins - blood
Humans
Interferon Type I - administration & dosage
Interferon Type I - pharmacology
Iron - blood
Lactoferrin - blood
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Time Factors
Tropical medicine
Human
Immunomodulator
Metabolic disorder
Toxicity
Africa
Ferritin
South Africa
Subcutaneous administration
Iron
Interferon
Blood
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ISSN0256-9574

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Summary:Subcutaneous administration of alpha-interferon to normal volunteers caused hypoferraemia and hyperferritinaemia. There was, however, no concomitant rise in other components of the acute-phase response, including the serum C-reactive protein value, the granulocyte count and the plasma lactoferrin concentration. In fact, the latter two dropped significantly. The hypoferraemic response could be prolonged when a second dose was given 48 hours after the initial one. This hypoferraemic response may play a role similar to that induced by interleukin-1, which limits the proliferation of invading micro-organisms or neoplastic cells. The present findings may therefore have relevance to the clinical mechanism of action of the interferons.
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ISSN:0256-9574