Differentiation-dependent expression of growth regulatory cytokines and their receptors in squamous cell carcinomas of the head and neck

Cytokines, such as IFN-alpha and TNF-alpha are capable of affecting keratinocyte proliferation in the microenvironment of the tumor. Their elevated expression along with high levels of their receptor mRNAs was determined by a semiquantitative reverse transcription- polymerase chain reaction (RT-PCR)...

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Bibliographic Details
Published inAnticancer research Vol. 19; no. 4C; p. 3623
Main Authors Arany, I, Brysk, M M, Chen, Z, Adler-Storthz, K, Tyring, S K
Format Journal Article
LanguageEnglish
Published Greece 01.07.1999
Subjects
Antigens, CD - biosynthesis
Antigens, CD - genetics
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Differentiation
Cytokines - analysis
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - pathology
Humans
Interferon-alpha - biosynthesis
Interferon-alpha - genetics
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Receptors, Interferon - biosynthesis
Receptors, Interferon - genetics
Receptors, Tumor Necrosis Factor - biosynthesis
Receptors, Tumor Necrosis Factor - genetics
Receptors, Tumor Necrosis Factor, Type I
Receptors, Tumor Necrosis Factor, Type II
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
Signal Transduction
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - genetics
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Summary:Cytokines, such as IFN-alpha and TNF-alpha are capable of affecting keratinocyte proliferation in the microenvironment of the tumor. Their elevated expression along with high levels of their receptor mRNAs was determined by a semiquantitative reverse transcription- polymerase chain reaction (RT-PCR) method in biopsies of head and neck squamous cell carcinomas that were established as histologically well or moderately differentiated. In contrast, tumors with poor differentiation exhibited low levels of these growth suppressive factors, although levels of their receptors were elevated. In fact, expression of these growth suppressive cytokines highly correlated with the histological status of tumors suggesting a role of these agents in growth regulation of those tumors. Apparently, growth signaling in these tumors differs in the availability of either the ligand or the receptor.
ISSN:0250-7005