Dynamics of postirradiation intracellular cysteine and aspartic proteinases profiles in proliferating and nonproliferating mammalian cells

Dynamics of postirradiation intracellular cysteine and aspartic proteinases profiles were examined in proliferating and nonproliferating Chinese hamster fibroblasts (V79). The results show that there are significant alterations in cysteine and aspartic intracellular proteinases activity already in t...

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Bibliographic Details
Published inStrahlentherapie und Onkologie Vol. 166; no. 6; p. 402
Main Authors Korbelik, M, Suhar, A, Osmak, M, Skrk, J, Turk, V
Format Journal Article
LanguageEnglish
Published Germany 01.06.1990
Subjects
Animals
Aspartic Acid Endopeptidases
Cell Division - physiology
Cell Division - radiation effects
Cells, Cultured - enzymology
Cells, Cultured - radiation effects
Cricetinae
Cricetulus
Cysteine Endopeptidases - metabolism
Cysteine Endopeptidases - radiation effects
Endopeptidases - metabolism
Endopeptidases - radiation effects
Fibroblasts - enzymology
Fibroblasts - radiation effects
Lung - enzymology
Lung - radiation effects
Radiation Tolerance
Time Factors
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Summary:Dynamics of postirradiation intracellular cysteine and aspartic proteinases profiles were examined in proliferating and nonproliferating Chinese hamster fibroblasts (V79). The results show that there are significant alterations in cysteine and aspartic intracellular proteinases activity already in the early postirradiation period, which are different in proliferating and nonproliferating cells. Irradiation of the cells examined to low doses and up to 15 Gy induced an increase in cysteine proteinases activity in the early postexposure period, while at higher irradiation doses applied, the activity of these proteinases was decreased. These observations suggest that intracellular proteinases are actively participating in process involving recovery from radiation injury or cell killing.
ISSN:0179-7158