A high performance electrochemical biosensor based on Cu2O-carbon dots for selective and sensitive determination of dopamine in human serum

• Published in: RSC advances Vol. 5; no. 67; pp. 5412 - 5418
• Main Authors: Huang, Qitong, Lin, Xiaofeng, Lin, Changqing, Zhang, Yong, Hu, Shirong, Wei, Chan
• Format: Journal Article
• Language: English
• Published: 19.06.2015
• Subjects: anions; biosensors; blood serum; cations; composite films; composite materials; cuprous oxide; detection limit; dopamine; electrodes; hematologic tests; ion exchange; moieties; nanoparticles
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/c5ra05433h

A green and facile method was developed by synthesizing a cuprous oxide-carbon dots/Nafion (Cu 2 O-CDs/NF) composite film for highly sensitive and reliable determination of dopamine (DA). The Cu 2 O nanoparticles could improve the conductivity of the electrode, while the CDs with carboxyl groups and the NF with sulfo groups could attract cations via the ion-exchange model and exclude anions by the electrostatic action. The proposed biosensor exhibited a low detection limit of 1.1 nM with a wide linear range of 0.05-45.0 μM and acquired excellent sensitivity and selectivity for DA. Furthermore, the Cu 2 O-CDs/NF/GCE also was applied to determine DA in human serum with satisfactory results and showed good activity for more than two months. A green and facile method was developed by synthesizing a cuprous oxide-carbon dots/Nafion (Cu 2 O-CDs/NF) composite film for highly sensitive and reliable determination of dopamine (DA).