Clinical significance of IgG anti-Sm antibodies in patients with systemic lupus erythematosus

Free Sm was purified by gel filtration and anti-Sm affinity chromatography. Using this purified antigen, an ELISA for anti-Sm was performed. Three hundred and fifty patients with various rheumatic diseases were studied with respect to immunoglobulin classes of anti-Sm by ELISA. A high frequency of I...

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Bibliographic Details
Published inJournal of rheumatology Vol. 17; no. 4; p. 469
Main Authors Yasuma, M, Takasaki, Y, Matsumoto, K, Kodama, A, Hashimoto, H, Hirose, S
Format Journal Article
LanguageEnglish
Published Canada 01.04.1990
Subjects
Adolescent
Adult
Aged
Antibodies, Antinuclear - analysis
Antibody Specificity
Autoantigens - immunology
Autoantigens - isolation & purification
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G - immunology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Male
Middle Aged
Ribonucleoproteins - immunology
Ribonucleoproteins, Small Nuclear
snRNP Core Proteins
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Summary:Free Sm was purified by gel filtration and anti-Sm affinity chromatography. Using this purified antigen, an ELISA for anti-Sm was performed. Three hundred and fifty patients with various rheumatic diseases were studied with respect to immunoglobulin classes of anti-Sm by ELISA. A high frequency of IgG anti-Sm was specifically detected in patients with systemic lupus erythematosus (SLE), but IgA and IgM anti-Sm showed a low frequency and also was detected in other diseases. In patients with SLE, anti-Sm significantly correlated with lung fibrosis and pericarditis. In our longitudinal study, there were increases in titer of IgG anti-Sm preceding central nervous system exacerbation and serositis. IgG anti-Sm was found to be not only a diagnostic marker but also a reliable measure of disease activity in SLE.
ISSN:0315-162X