The role of anticholinergics in bronchoscopy: A randomized clinical trial

• Published in: Chest Vol. 118; no. 1; pp. 188 - 192
• Main Authors: COWL, C. T, PRAKASH, U. B. S, KRUGER, B. R
• Format: Journal Article
• Language: English
• Published: Northbrook, IL American College of Chest Physicians 01.07.2000
• Subjects: Aged; Atropine - therapeutic use; Biological and medical sciences; Bronchoscopy; Double-Blind Method; Endoscopy; Female; Glycopyrrolate - therapeutic use; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Muscarinic Antagonists - therapeutic use; Pain Measurement; Premedication; Prospective Studies; Bronchoscopy; Human; Treatment efficiency; Exploration; Quaternary ammonium compound; Cholinergic receptor; Chemotherapy; Treatment; Glycopyrronium bromide; Atropine; Benzodiazepine derivatives; Combined treatment; Antagonist; Endoscopy; Sedative; Midazolam; Technique; Comparative study; Premedication
• ISSN: 0012-3692; 1931-3543
• DOI: 10.1378/chest.118.1.188

Anticholinergic medications have been utilized frequently prior to bronchoscopy and are thought to facilitate the drying of secretions to limit the amount of required topical anesthetic on the airway mucosa, prevent cardiac arrhythmias during the procedure, and increase patient comfort. To determine if atropine or glycopyrrolate, two anticholinergic agents utilized most frequently in this setting, have any significant role for this purpose. Double-blind, placebo-controlled study, in which patients were randomly selected to receive atropine (0.01 mg/kg body weight, IM injection), glycopyrrolate (0.005 mg/kg, IM injection), or saline solution placebo (approximately 2 mL, IM injection) 15 to 45 min prior to being sedated with midazolam until judged to be lightly sedated. A large academic teaching hospital in the midwestern United States. Two hundred seventeen outpatients referred for bronchoscopy who satisfied inclusion and exclusion criteria. Using a modified visual analog scale (0 to 100 mm), the bronchoscopist and the nurse anesthetist estimated the antisialagogic effect, effectiveness in cough suppression, and overall patient comfort during the procedure. The patients completed a similar questionnaire after recovering from the procedure. Patients were also monitored for complications (cardiac arrhythmias, oxygen desaturation, hypertension, wheezing, or coughing severe enough to curtail the procedure). There was no significant difference found among atropine, glycopyrrolate, and placebo for the primary end point of secretion control. In addition, there was no difference found between either medication and placebo for effectiveness of cough suppression, amount of topical anesthetic used, complication rates, or overall patient comfort. The use of anticholinergic agents prior to bronchoscopy did not affect performance of bronchoscopy or complication rates, and there was no appreciable benefit from the resultant reduction in airway secretions in a population of patients receiving concurrent sedation with benzodiazepines.