Antituberculosis agents, I: Synthesis and antituberculosis activity of 2-aryl-1,3,4-thiadiazole derivatives
The design, synthesis and antituberculosis activity of a series of 2-aryl-5-methylthio-1,3,4-thiadiazoles (5a-b), ethyl alpha-(5-aryl)-1,3,4-thiadiazole-2-ylthio)acetates (8a-b) and related compounds are described. All of the compounds were tested against Mycobacterium tuberculosis strain H37Rv in c...
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Published in | Pharmazie Vol. 56; no. 8; pp. 610 - 612 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
ESCHBORN
Govi-Verlag Pharmazeutischer Verlag Gmbh
01.08.2001
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Subjects | |
Online Access | Get more information |
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Summary: | The design, synthesis and antituberculosis activity of a series of 2-aryl-5-methylthio-1,3,4-thiadiazoles (5a-b), ethyl alpha-(5-aryl)-1,3,4-thiadiazole-2-ylthio)acetates (8a-b) and related compounds are described. All of the compounds were tested against Mycobacterium tuberculosis strain H37Rv in comparison to rifampicin. Six compounds exhibited a very good activity (MIC < 6.25 mug/ml, % Inhibition = 100). |
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ISSN: | 0031-7144 |