Antituberculosis agents, I: Synthesis and antituberculosis activity of 2-aryl-1,3,4-thiadiazole derivatives

The design, synthesis and antituberculosis activity of a series of 2-aryl-5-methylthio-1,3,4-thiadiazoles (5a-b), ethyl alpha-(5-aryl)-1,3,4-thiadiazole-2-ylthio)acetates (8a-b) and related compounds are described. All of the compounds were tested against Mycobacterium tuberculosis strain H37Rv in c...

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Bibliographic Details
Published inPharmazie Vol. 56; no. 8; pp. 610 - 612
Main Authors Foroumadi, A, Mirzaei, M, Shafiee, A
Format Journal Article
LanguageEnglish
Published ESCHBORN Govi-Verlag Pharmazeutischer Verlag Gmbh 01.08.2001
Subjects
Acetates - chemical synthesis
Acetates - pharmacology
Antitubercular Agents - chemical synthesis
Antitubercular Agents - pharmacology
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Life Sciences & Biomedicine
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Mycobacterium tuberculosis - drug effects
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
Spectrophotometry, Infrared
Thiadiazoles - chemical synthesis
Thiadiazoles - pharmacology
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Summary:The design, synthesis and antituberculosis activity of a series of 2-aryl-5-methylthio-1,3,4-thiadiazoles (5a-b), ethyl alpha-(5-aryl)-1,3,4-thiadiazole-2-ylthio)acetates (8a-b) and related compounds are described. All of the compounds were tested against Mycobacterium tuberculosis strain H37Rv in comparison to rifampicin. Six compounds exhibited a very good activity (MIC < 6.25 mug/ml, % Inhibition = 100).
ISSN:0031-7144