Changes in soluble interleukin-2 receptor level in serum and Na+-K+- exchanging ATPase activity in semen of infertile men caused by antisperm antibody

• Published in: Asian journal of andrology Vol. 2; no. 2; pp. 151 - 153
• Main Authors: NI, J, LI, Q.-L, ZHANG, W, XIE, J.-S, BIAN, S.-L
• Format: Journal Article
• Language: English
• Published: Oxford blackwell 01.06.2000
• Subjects: Adult; Autoantibodies - immunology; Biological and medical sciences; Birth control; Gynecology. Andrology. Obstetrics; Humans; Infertility, Male - immunology; Infertility, Male - metabolism; Male; Medical sciences; Receptors, Interleukin-2 - blood; Semen - enzymology; Sodium-Potassium-Exchanging ATPase - metabolism; Spermatozoa - enzymology; Spermatozoa - immunology; Sterility. Assisted procreation; Human; Immunopathology; Enzyme; Antibody; Semen; Cytokine; Male; K; Na; Interleukin 2; Immunological investigation; Hydrolases; exchanging ATPase; Male sterility; Male genital diseases; Biological receptor
• ISSN: 1008-682X; 1745-7262

To explore the possible mechanisms of male infertility caused by antisperm antibody (AsAb). The soluble interleukin-2 receptor (sIL-2R) level in serum was analyzed by ELISA and Na+-K+-exchanging ATPase activity in semen by phosphorus (Pi) assay. The sIL-2R level in serum was significantly higher and the Na+K+-exchanging ATPase activity in semen significantly lower in AsAb positive infertile men when compared with the controls. The AsAb titer varies with the sIL-2R level in serum. A decrease in Na+-K+-exchanging ATPase activity in semen may play a role in male infertility caused by AsAb.