Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers

The pharmacokinetics of dimetindene (dimethindene maleate, Fenistil, CAS 3614-69-5) were studied after its intravenous and oral administration to 8 healthy male volunteers. Serum concentrations were measured for 48 h using an enzyme-linked immunosorbent assay. Pharmacokinetic parameters (AUC, t1/2,...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 40; no. 12; p. 1346
Main Authors Arnera, V, Wermeille, M, Wellman, M, Llull, J B, Althaus, M A, Balant, L P
Format Journal Article
LanguageEnglish
Published Germany 01.12.1990
Subjects
Administration, Oral
Adult
Biological Availability
Chromatography, Gas
Dimethindene - administration & dosage
Dimethindene - pharmacokinetics
Enzyme-Linked Immunosorbent Assay
Half-Life
Humans
Injections, Intravenous
Male
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Summary:The pharmacokinetics of dimetindene (dimethindene maleate, Fenistil, CAS 3614-69-5) were studied after its intravenous and oral administration to 8 healthy male volunteers. Serum concentrations were measured for 48 h using an enzyme-linked immunosorbent assay. Pharmacokinetic parameters (AUC, t1/2, CLs, Vd and F) were calculated using the clearance approach.
ISSN:0004-4172