Protection by pyroglutamic acid and some of its newly synthesized derivatives against glutamate-induced seizures in mice

The protection by pyroglutamic acid (CAS 98-79-3) and derivatives Ia-i (injected i.p.) against glutamate- and NMDA (N-methyl-D-aspartate) (i.c.v.) induced seizures in mice has been studied in comparison with known antiepileptics and antagonists of excitatory aminoacids. The potency of pyroglutamic a...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 40; no. 11; p. 1187
Main Authors Beani, L, Bianchi, C, Baraldi, P G, Manfredini, S, Pollini, G P
Format Journal Article
LanguageEnglish
Published Germany 01.11.1990
Subjects
Animals
Anticonvulsants
Behavior, Animal - drug effects
Glutamates
Glutamic Acid
Indicators and Reagents
Injections, Intraperitoneal
Injections, Intraventricular
Male
Mice
Motor Activity - drug effects
N-Methylaspartate
Pyrrolidonecarboxylic Acid - analogs & derivatives
Pyrrolidonecarboxylic Acid - chemical synthesis
Pyrrolidonecarboxylic Acid - pharmacology
Seizures - chemically induced
Seizures - prevention & control
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Summary:The protection by pyroglutamic acid (CAS 98-79-3) and derivatives Ia-i (injected i.p.) against glutamate- and NMDA (N-methyl-D-aspartate) (i.c.v.) induced seizures in mice has been studied in comparison with known antiepileptics and antagonists of excitatory aminoacids. The potency of pyroglutamic acid and some derivatives (Id,f,g,h) against glutamate-induced convulsions was similar to that shown by glutamic acid diethylester and by valproic acid. Interestingly, pyroglutamic acid did not affect NMDA-induced convulsions which were well antagonized by both 2-amino-5-phosphono valeric acid and by diazepam. Thus, pyroglutamic acid may represent the starting for synthesis of excitatory aminoacid antagonists acting at non NMDA receptors.
ISSN:0004-4172