The non-surgical treatments of hepatocellular carcinomas in a patient with severe hemophilia A

We recently treated a patient with multiple hepatocellular carcinomas (HCC) who had severe hemophilia A and thrombocytopenia secondary to cirrhosis. He was not a candidate for surgery because of his liver failure. Transcatheter arterial chemoembolization and percutaneous ethanol injection therapy we...

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Bibliographic Details
Published inHepato-gastroenterology Vol. 46; no. 26; p. 1156
Main Authors Toyoda, H, Fukuda, Y, Nakano, I, Katano, Y, Ebata, M, Morita, K, Nagano, K, Yokozaki, S, Takeuchi, M, Hayashi, K, Hayakawa, T, Takamatsu, J
Format Journal Article
LanguageEnglish
Published Greece 01.03.1999
Subjects
Adult
Angiography
Carcinoma, Hepatocellular - blood supply
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - therapy
Chemoembolization, Therapeutic
Combined Modality Therapy
Epirubicin - administration & dosage
Ethanol - administration & dosage
Factor VIII - administration & dosage
Factor VIII - metabolism
Hemophilia A - complications
Hemophilia A - diagnostic imaging
Hemophilia A - therapy
Humans
Injections, Intralesional
Liver Neoplasms - blood supply
Liver Neoplasms - complications
Liver Neoplasms - therapy
Male
Tomography, X-Ray Computed
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Summary:We recently treated a patient with multiple hepatocellular carcinomas (HCC) who had severe hemophilia A and thrombocytopenia secondary to cirrhosis. He was not a candidate for surgery because of his liver failure. Transcatheter arterial chemoembolization and percutaneous ethanol injection therapy were successfully performed without complications by maintaining factor VIII levels above 40%. We believe that the non-surgical treatment of HCC can be performed safely in patients with coagulation disorders, by the appropriate administration of coagulation factors, despite thrombocytopenia and/or elongation of the prothrombin time from cirrhosis.
ISSN:0172-6390